Cell models and biotechnology

概观

The Cell Models and Biotechnology group focuses on the application of the life sciences to the fields of engineering, medicine and technology - with particular emphasis on their use in regenerative medicine and drug formulation, manufacture and delivery.

The group primarily develops accurate and biosensitive, in-vitro-in vivo 500 Internal Server Error

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Ultimately, the development of these more accurate and predictive cell models play a pivotal role in the translation and assessment of drugs for safety and use in clinical practice.

What the group does

The Cell Models and Biotechnology group focuses on the 体外 model design, characterisation and validation of tissues and/or organs of interest. In addition, exploitation of these engineered models are used to assess toxicity and efficacy characteristics of novel compounds or therapeutics.  Specific research interests include:

  • Development of advanced 3D cell culture models of (human) skin, eye, lung and liver for toxicity testing i.e. environmental and pharmaceutical
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  • Characterisation and development of novel biomaterials and drug delivery carriers
  • Development of a desiccation-tolerant cell lines and/or addressing challenges associated with long-term storage of (human/mammalian/stem) cell lines
  • Optimisation of processing parameters for (large-scale) cell generation and manufacture
  • Development of alternative scientific methods and techniques for 3Rs research

Services offered

  • 2D and 3D toxicity screening using advanced ocular, airway, GI and skin cell models
  • Development of new screening platforms and cultures that are more biologically relevant and with desired/specific endpoint parameters
  • Permeability modelling including transporter-mediated drug trafficking (including radiolabelled compounds)
  • Cell surface marker and cytokine/chemokine expression i.e. ELISA and flow cytometry
  • Long term cell viability assessment, characterisation and validation
  • Biomaterial characterisation and assessment i.e. physical/biological/rheological