Patient-centric product design has gained much attention in pharmaceutical development in recent years. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in pharmaceutical development. Age-appropriate formulation design and selection for paediatric and geriatric patients can have an impact on patient safety, therapeutic outcomes and adherence.
Whilst children and older adults share similarities in medication administration and formulation needs, distinct differences in relation to drug therapy are notable and separate considerations in formulation development and drug delivery should be given to the two populations. Palatability and ease of administration are the critical factors affecting acceptability of paediatric patients’ to a medicinal product. A risk-benefit based approach can be effective in the selection and design of appropriate paediatric formulations.
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The age-appropriate drug delivery group focuses on the understanding of the pharmaceutical needs of paediatric and geriatric patients and the development of novel formulations to meet these needs, such as: